Radiobiological modeling of interplay between accelerated repopulation and altered fractionation schedules in head and neck cancer
نویسندگان
چکیده
منابع مشابه
Head and neck cancer: altered fractionation schedules.
Local control is paramount in the treatment of localized advanced head and neck cancer. Standard radiotherapy cures a high percentage of early tumors--more than 80% of the early laryngeal tumors--but fewer of the advanced tumors. Attempts have therefore been made to improve the therapeutic ratio by: A) hyperfractionation: reducing the dose per fraction to reduce late morbidity; the total dose i...
متن کاملAltered fractionation for head and neck cancer.
A conventional course of radiation for squamous cell carcinoma in the United States is generally 70 Gy in 7 weeks, with a once-daily dose of 1.8 to 2 Gy. This schedule has a modest success rate in curing head and neck cancer. The past several decades have seen numerous investigations into altering this schedule to optimize the results of radiation. Two approaches, founded on radiobiologic princ...
متن کاملAltered Fractionation for Head and Neck Cancer
Delivery of therapeutic radiation in multiple sessions, or fractions, has been practiced since the discovery of radiation’s potential to cure malignancies. Initially, this was done out of practical necessity: Radiation was delivered at a low dose rate, and the treatment sessions had to be repeated to obtain the desired effect. Technologic improvements eventually allowed for treatments in one se...
متن کاملRole of Altered Fractionation & Chemoradiation in Head and Neck Cancer
Dividing a dose into a number of fractions spares normal tissues because of repair of SLD between dose fractions and repopulation of cells if the overall time is sufficiently long. At the same time dividing a dose into a number of fractions increases the damage to the tumor because of reoxygenation and reassortment of cells into radiosensitive phases of the cell cycles between dose fractions. T...
متن کاملA prospective radiobiological study of acute esophagitis and swallowing dysfunction in head-and-neck radiotherapy
Introduction: Esophagitis is one of the main causes of swallowing dysfunction after radiation therapy (RT) for head and neck cancer (HNC).It significantly affects patients’ quality of life as well as having a potentially negative impact on their long term survival. However, little has been investigated on the dose-response and normal tissue complication probability (NTCP) of es...
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ژورنال
عنوان ژورنال: Journal of Medical Physics
سال: 2009
ISSN: 0971-6203
DOI: 10.4103/0971-6203.56081